Ikaros Monoclonal Antibody - BT-MCA0103

Ikaros Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0103-50, BT-MCA0103-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding

Research Areas: Signal transduction; Cancer

Target Protein: IKZF1

Applications: WB

Reactivity: Human,Mouse,Dog

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: DNA-binding protein Ikaros

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q13422; Mouse: Q03267

Synonyms: IKZF1; IK1; IKAROS; LYF1; ZNFN1A1; DNA-binding protein Ikaros; Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1

GeneID: Human: 10320

Research Use Only