Product Description

IL-10 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA11506-50, RA11506-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: interleukin 10 (IL10) Homo sapiens The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011],

Reactivity: Human

Host: Mouse

Applications: WB, ELISA

Alternate Names: IL10, Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF

Clonality: Monoclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Storage: -20°C/1 year

Condition: Purified antibody in PBS containing 0.03% sodium azide.

Human Gene ID: 3586

Research Use Only