Product Description

IL-12B p40 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA26243-50, RA26243-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: interleukin 12B (IL12B) Homo sapiens This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provi

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC-p, IF (paraffin section), ELISA

Alternate Names: Interleukin-12 subunit beta (IL-12B;Cytotoxic lymphocyte maturation factor 40 kDa subunit;CLMF p40;IL-12 subunit p40;NK cell stimulatory factor chain 2;NKSF2)

Clonality: Polyclonal

Dilution: WB 1:500-2000, IHC-p 1:500-200, ELISA 1:10000-20000

Molecular Weight: 40

Protein Molecular Weight (kDa): 40

Storage: -20°C/1 year

Human Gene ID: 3593

Human SwissProt Number: P29460

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only