IL-13R/CD213a1 Recombinant Protein - NCP0238

IL-13R/CD213a1 Recombinant Protein

Catalogue Number: NCP0238-500, NCP0238-1000

Sizes: 500ug, 1mg

Swiss-Prot: P78552

Host: E.coli

Tag: His-tag

AA Sequence: GGTGGTGGTGGTGCAGCCCCTACCGAAACACAACCGCCGGTTACCAATCTGAGTGTTAGCGTGGAAAATCTGTGTACCGTTATCTGGACCTGGAATCCGCCGGAAGGCGCAAGCAGCAATTGTAGCCTGTGGTACTTCAGTCACTTCGGCGATAAACAGGATAAAAAAATTGCACCGGAAACCAGACGTAGTATTGAAGTGCCGCTGAATGAACGCATCTGTCTGCAGGTTGGCAGCCAGTGTAGTACCAATGAAAGCGAAAAACCGAGCATTCTGGTTGAAAAATGTATTAGCCCGCCGGAAGGTGATCCGGAAAGTGCAGTTACCGAACTGCAGTGCATCTGGCATAATCTGAGCTATATGAAATGTAGCTGGCTGCCGGGTCGTAATACCAGTCCGGATACCAATTATACCCTGTATTATTGGCATCGTAGTCTGGAAAAAATTCATCAGTGCGAAAATATCTTCCGCGAAGGTCAGTACTTCGGTTGTAGCTTCGATCTGACCAAAGTGAAAGATAGCAGCTTCGAACAGCATAGCGTGCAGATTATGGTTAAAGATAATGCAGGTAAAATCAAGCCGAGCTTCAATATTGTGCCGCTGACCAGTCGTGTTAAACCGGATCCGCCGCATATTAAAAATCTGAGCTTCCATAATGACGATCTGTATGTTCAGTGGGAAAATCCGCAGAACTTCATTAGTCGCTGCCTGTTCTATGAAGTTGAAGTTAATAATAGCCAGACCGAAACACATAATGTGTTCTATGTTCAGGAAGCAAAATGTGAAAATCCGGAATTCGAACGTAATGTGGAAAATACCAGTTGCTTCATGGTGCCGGGCGTTCTGCCGGATACCCTGAATACCGTGCGCATTCGCGTTAAAACCAATAAACTGTGCTATGAAGATGATAAACTGTGGAGTAATTGGAGCCAGGAAATGAGCATTGGCAAAAAACGCAATAGTACC

Restriction Sites: NdeI-XhoI

Background: The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Ra1 and 2. IL-13Ra1 exists as a heterodimer of IL-13Ra1 and IL-4Ra as a signaling subunit, whereas IL-13Ra2 acts as a decoy receptor for IL-13. Furthermore, TNFa or IL-4 stimulation induces IL-13Ra2 upregulation, while IL-13Ra1 is constitutively expressed. Cell surface localization of IL-13Ra2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Ra1 expression is predominant in B cells, monocytes and
T cells, whereas IL-13Ra2 expression is highest in glioma cells.

Soluble: PBS, 4M Urea, PH7.4

Purification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Expression Vector: pet-22b(+)

BioWorld Molecular Weight: ~32kDa

Notes: For research use only, not for use in diagnostic procedure.