Product Description

IL-2 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67037-50, MB67037-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Interleukin-2 (IL-2) is a T cell stimμlatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation . IL-2 also promotes peripheral development of regμlatory T cells (Tregs) . Conversely, IL-2 is involved in the activation-induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells . The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ, and the common gamma chain, γc . IL-2Rα binds exclusively to IL-2 with low affinity and increases the binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-15 also binds to IL-2Rβ . γc is used by other cytokines, including IL-4, IL-7, IL-9, IL-15, and IL-21 . Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5, and the PI3K/Akt pathways .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Interleukin-2, IL-2, T-cell growth factor, TCGF, Aldesleukin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-2. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of IL-2 protein.

Molecular Weight: ~ 17 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P60568

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only