Product Description

IL-22Rα2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60293-50, BS60293-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: IL-22Rα2 (interleukin-22 receptor α-2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2 soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22Rα2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is four- to ten-fold higher than that of the membrane bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22Rα2 prevents the binding to the IL-22 membrane bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22Rα2 may be important in regμlating inflammatory responses. In addition, IL-22Rα2 can be induced by lipopolysaccharide (LPS).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Interleukin-22 receptor subunit alpha-2, IL-22 receptor subunit alpha-2, IL-22R-alpha-2, IL-22RA2, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, CRF2-10, Cytokine receptor family type 2, soluble 1, CRF2-S1, Interleukin-22-binding protein, IL-22BP, IL22BP, ZcytoR16, IL22RA2, UNQ5793/PRO19598/PRO19822

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human IL-22Rα2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IL-22Rα2 polyclonal antibody detects endogenous levels of IL-22Rα2 protein.

Molecular Weight: ~ 30 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q969J5

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only