Product Description

IL-4 Rat Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB65863-50, MB65863-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: IL-4 is produced by T cells, NK T cells, γδ cells, and mast cells. Target cells include B cells, T cells, and macrophages. IL-4 induces the polarization of naïve helper T cells into the TH2 phenotype. IL-4 also promotes B cell proliferation, antibody class switching and the production other TH2 cytokines including IL-5 and IL-9. IL-4 induced TH2 polarization is important in developing humoral immunity against extracellμlar pathogens and is involved in the development of allergy and asthma. IL-4 binds to two distinct receptors, the Type I receptor and Type II receptor. Type I receptor is a heterodimer consisting of IL-4Rα chain and the common gamma chain, γc. Type II receptor, which is shared with IL-13, is a heterodimer of IL-4Rα and IL-13Rα1. Signaling initiated via Type I receptor resμlts in the activation of Jak1/Stat6, Jak3 and the PI3K/Akt pathways. The Type II receptor activates the Jak1/Stat6 and the Tyk2/Stat3 pathways.

Category: Primary Antibody

Reactivity: Mouse

Host: Rat

Applications: IF, FC

Alternate Names: Interleukin-4, IL-4, B-cell stimμlatory factor 1, BSF-1, Binetrakin, Lymphocyte stimμlatory factor 1, Pitrakinra

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Dilution: IF (1/50 - 1/200)

Purification: The monoclonal antibody was affinity-purified from rat antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes mouse IL-4

Molecular Weight: ~ 15 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P07750

Product: Rat IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Research Use Only