IL-4R Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS65584-50, BS65584-100 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Swiss-Prot: Q63257 Host: Rabbit Reactivity: Mouse, Rat, Applications: WB, All Applications: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Background: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008]. Purification and Purity: affinity purified by Protein A Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: IL-4R polyclonal Antibody detects endogenous levels of IL-4R protein. Bioworld Molecular Weight: ~140kDa Note: For research use only, not for use in diagnostic procedure. Extra Notes: Anti- IL-4R at 1/1000 dilution, Anti- IL-4R at 1/1000 dilution, Anti- IL-4R at 1/1000 dilution Alternative Name: CD124; IL 4R alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; IL4R nirs variant 1; IL4RA; IL4RA_HUMAN; Interleukin 4 receptor alpha chain; Interleukin 4 receptor; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha. Immunogen: KLH conjugated synthetic peptide derived from rat IL-4R:111-210/801 Conjugate: Unconjugated Modification: Unmodified