IL-8Rβ (D343) Polyclonal Antibody-BS1801

IL-8Rβ (D343) Polyclonal Antibody

Catalogue Numbers: BS1801-50, BS1801-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P25025

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: IL-8 has been shown to function as a potent neutrophil chemostatic and activating peptide and is an important mediator of inflammatory diseases. Two distinct human IL-8 receptors, designated IL-8RA and IL-8RB, have been characterized. Both are expressed at a high level on neutrophils and, to a lesser extent, on monocytes and myeloid cell lines. In addition, the IL-8RA subunit is expressed in T cells such as the Jurkat cell line. Both IL-8Rs are members of the seven transmembrane domain rhodopsin superfamily of receptors and, as such, couple G proteins for signal transduction. The 2 receptors share 77% amino acid identity. IL-8RA exhibits high affinity binding for IL-8 and low affinity MGSA binding, whereas IL-8RB has high affinity binding for both IL-8 and MGSA

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IL-8Rβ (D343) pAb detects endogenous levels of IL-8Rβ (D343) protein.

Extra Notes: Western blot (WB) analysis of IL-8Rβ (D343) pAb at 1:500 dilution
Lane1:K562 whole cell lysate(40ug)
Lane2:EC9706 whole cell lysate(40ug)
Lane3:A549 whole cell lysate(40ug)
Lane4:PMVEC whole cell lysate(40ug)
Lane5:AML-12 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha; PIK3R1; GRB1

Immunogen: Synthetic peptide, corresponding to Human MYLK.

Conjugate: Unconjugated

Modification: Unmodified