IL27RA Polyclonal Antibody
Catalogue Numbers: BS61323-50, BS61323-100
Sizes: 50µl, 100µl
Alternative Name: Interleukin-27 receptor subunit alpha; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; Cytokine receptor WSX-1; Cytokine receptor-like 1; Type I T-cell cytokine receptor; TCCR; ZcytoR1; IL27RA; CRL1; TCCR; WSX1
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q6UWB1
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: IL-27 is a heterodimeric cytokine that consists of EBI3, an IL-12p40-related protein, and p28, a IL-12p35-related polypeptide. IL-27 triggers expansion of antigen-specific naive CD4-positive T cells and promotes polarization towards a Th1 phenotype with expression of gamma-interferon. IL-27 contributes to the development of an adaptive immune response through its action on CD4-positive T cells, and also directly acts on cells of the innate immune system. IL-27 protein levels increase upon activation of antigen-presenting cells. IL-27 protein induces orphan cytokine receptor IL-27R (WSX-1)-dependent clonal expansion of naive but not memory CD4(+) T cells. IL-27 signaling through IL-27R and gp130 also induces phosphorylation of Stat1-5.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -27°C long term. Avoid freeze-thaw cycles.
Specificity: IL27RA polyclonal antibody detects endogenous levels of IL27RA protein.
Bioworld Molecular Weight: ~ 69 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of IL27RA polyclonal antibody at 1:500 dilution
Line1:HEPG2 whole cell lysate
Line2:Raw264.7 whole cell lysate
Line3:The Liver tissue lysate of Rat
Immunogen: A synthetic peptide corresponding to residues in Human IL27RA.
Conjugate: Unconjugated
Modification: Unmodified