Product Description

IMP3 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0144-50, MB0144-100

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O00425

Host: Mouse IgG1

Reactivity: Human

Applications: WB

All Applications: WB: 1:1000

Background: Imp3, also known as BRMS2, C15orf12 or MRPS4, is a 184 amino acid protein that contains one S4 RNA-binding domain and is the mammalian homolog of the yeast Imp3 protein. Localized to the nucleus, Imp3 exists as a component of a heterotrimeric complex consisting of MPP10, Imp3 and Imp4 and, in this complex, plays a key role in early cleavage events during pre-18S ribosomal processing. The gene encoding Imp3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of IMP3 and does not cross-react with related proteins

Bioworld Molecular Weight: Predicted band size:70KDa
Observed band size:70KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western BlotDetection of IMP3 antibody in MCF7, SKVO3, NTERA2, Jurkat, Hela and K562 cell lysates using IMP3 antibody (1:1000 diluted).

Alternative Name: Insulin-like growth factor 2 mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3; IGF2BP3; IMP3; KOC1; VICKZ3

Immunogen: Recombinant full length Human IMP3.

Conjugate: Unconjugated

Modification: Unmodified