INHA Polyclonal Antibody
Catalogue Numbers: BS60979-50, BS60979-100
Sizes: 50µl, 100µl
Alternative Name: Inhibin alpha chain; INHA
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P05111
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
IHC: 1:50~1:203
Background: Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same α subunit, covalently linked to 1 of 2 distinct subunits, β-α or β-β. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, inhibin belongs to the transforming growth factor β (TGFβ) superfamily of growth and differentiation factors. TGFβ proteins affect a range of tissues and systems beyond their role in reproduction. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, placenta and, most notably, anterior pituitary. Inhibin α-subunit gene expression is down regulated in human prostate cancer, suggesting a tumor-suppressive role. The human Inhibin α gene maps to chromosome 2q33-q36.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: INHA polyclonal antibody detects endogenous levels of INHA protein.
Bioworld Molecular Weight: ~ 40 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of INHA polyclonal antibody at 1:500 dilution
Lane 1: sp2/0 whole cell lysate
Lane 2: PC12 whole cell lysate
Lane 3: H9C2 whole cell lysate
Lane 4: A549 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human INHA.
Conjugate: Unconjugated
Modification: Unmodified