Product Description

INP5E Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA32810-50, RA32810-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: inositol polyphosphate-5-phosphatase E (INPP5E) Homo sapiens The protein encoded by this gene is an inositol 1, 4, 5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins (1, 4, 5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3, 4, 5-trisphosphate and phosphatidylinositol 3, 5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 70

Protein Molecular Weight (kDa): 70

Storage: -20°C/1 year

Human Gene ID: 56623

Human SwissProt Number: Q9NRR6

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only