Product Description

INSL3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7819-50, BS7819-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P51460

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

All Applications: WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100

Background: Insulin-like factor 3 (INSL3), also designated Leydig insulin-like peptide (Ley IL) and Relaxin-like factor (RLF), is a peptide hormone in the Relaxin family which is secreted from the testicular Leydig cells and ovarian theca interna cells. INSL3 is involved in gonadal and other physiological processes. Structurally similar to Relaxin and insulin, INSL3 differs from the two in that it signals through a G protein-coupled receptor, LGR8. INSL3/LGR8 signaling is involved in gubernaculum development and transabdominal testicular descent during development. Abnormal INSL3 production or action by the fetal testis causes cryptorchidism, a developmental defect of the urogenital tract in human males wherein the testis do not descend into the scrotum during embryonic development. Infertility and the development of germ-cell tumors are two potential risks for individuals with cryptorchidism.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: INSL3 polyclonal antibody detects endogenous levels of INSL3 protein.

Bioworld Molecular Weight: ~ 14 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of INSL3 polyclonal antibody

Alternative Name: INSL 3;
INSL 3;
INSL3;
INSL3_HUMAN;
Insulin like 3;
Insulin-like 3 A chain;
Ley IL;
Ley-I-L;
Leydig insulin like peptide;
Leydig insulin-like peptide;
Relaxin like factor;
Relaxin-like factor;
RLF;
RLNL;

Immunogen: Recombinant full length Human INSL3.

Conjugate: Unconjugated

Modification: Unmodified