Product Description

INSL3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7819-50, BS7819-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Insμlin-like factor 3 (INSL3), also designated Leydig insμlin-like peptide (Ley IL) and Relaxin-like factor (RLF), is a peptide hormone in the Relaxin family which is secreted from the testicμlar Leydig cells and ovarian theca interna cells. INSL3 is involved in gonadal and other physiological processes. Structurally similar to Relaxin and insμlin, INSL3 differs from the two in that it signals through a G protein-coupled receptor, LGR8. INSL3/LGR8 signaling is involved in gubernacμlum development and transabdominal testicμlar descent during development. Abnormal INSL3 production or action by the fetal testis causes cryptorchidism, a developmental defect of the urogenital tract in human males wherein the testis do not descend into the scrotum during embryonic development. Infertility and the development of germ-cell tumors are two potential risks for individuals with cryptorchidism.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC-P, IF/ICC, ELISA

Alternate Names: INSL 3, INSL-3, INSL3_HUMAN, Insμlin like 3, Insμlin-like 3 A chain, Ley IL, Ley-I-L, Leydig insμlin like peptide, Leydig insμlin-like peptide, Relaxin like factor, Relaxin-like factor, RLF, RLNL

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 ofhuman INSL3 (NP_005534.2).

Dilution: IHC-P 1:50 - 1:100
IF/ICC 1:50 - 1:100
ELISA 1:5000 - 1:10000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: INSL3 polyclonal antibody detects endogenous levels of INSL3 protein.

Molecular Weight: ~ 15 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P51460

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only