Insulin Polyclonal Antibody - BT-AP10406

Insulin Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP10406-20, BT-AP10406-50, BT-AP10406-100

Citations, Manuals and MSDS Available upon request.

Background: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5andapos; region and with the IGF2 gene at the 3andapos; region. Alternative splicing results in multiple transcript variants.

Research Areas: Signal transduction; Cardiovascular; Metabolism; Neuroscience; Cancer

Target Protein: INS

Applications: IHC-p, IF, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Insulin [Cleaved into: Insulin B chain; Insulin A chain]

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P01308

Synonyms: Insulin [Cleaved into: Insulin B chain; Insulin A chain]; Insulin [Cleaved into: Insulin B chain; Insulin A chain;

GeneID: Human: 3630; Mouse: 0

Research Use Only