Product Description

Insulin R Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA26383-50, RA26383-100

Citations, Manuals and MSDS Available upon request.

Background: insulin receptor (INSR) Homo sapiens This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-200, ELISA 1:10000-20000

Alternative Names: Insulin receptor (IR;EC 2.7.10.1;CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]

Applications: IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 3643

SWISS: P06213

Source: Rabbit

Research Use Only