Integrin α2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90719-50, BS90719-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P17301(Human) Q62469(Mouse) Unigene:83597(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF, IHC, IP, , FC
All Applications: WB:1:1,000-1:5,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:50-1:100
Background: Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The sixteen α and eight β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counter-receptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin α2 is responsible for adhesion of platelets and other cells to collagens. Modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Integrin α2 polyclonal antibody detects endogenous levels of Integrin α2 protein.
Bioworld Molecular Weight: 150 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of ITGA2 on A431 cells lysates using anti-ITGA2 antibody at 1/1,000 dilution., ICC staining ITGA2 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: GPIa, ITGA2, BR, CD 49b, CD49 antigen like family member B, CD49 antigen-like family member B, CD49b, CD49b antigen, Collagen receptor, DX5, Glycoprotein Ia deficiency included, GP Ia, GP Ia deficiency, included, GPIa, HPA 5 included, HPA5 included, Human platelet alloantigen system 5, Integrin alpha 2, Integrin alpha-2, Integrin, alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor), ITA2, ITGA2, Platelet alloantigen Br(a), included, Platelet antigen Br, Platelet glycoprotein GPIa, Platelet glycoprotein Ia, Platelet glycoprotein Ia/IIa, Platelet membrane glycoprotein Ia, Platelet receptor for collagen, deficiency of, included, Very late activation protein 2 receptor alpha 2 subunit, VLA 2 alpha chain, VLA 2, VLA 2 subunit alpha, VLA-2 subunit alpha, VLA2, VLA2 receptor alpha 2 subunit, VLAA2,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified