Product Description

Integrin β3 (phospho-Y773) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4103-50, BS4103-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16α and 8β subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellμlar matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellμlar adhesion molecμles (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors, both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Integrin beta-3, Platelet membrane glycoprotein IIIa, Short name=GPIIIa, CD_antigen=CD61, ITGB3, GP3A, CD61, GPIIIa,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human Integrin β3 around the phosphorylation site of Tyrosine 773.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-Integrin β3 (Y773) polyclonal antibody detects endogenous levels of Integrin β3 protein only when phosphorylated at Tyr773.

Molecular Weight: ~ 87, 110 kDa

Pathway: Tumor Angiogenesis, Contribution of ECM and Cytoskeletal Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P05106

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only