Product Description

Integrin β3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90726-50, BS90726-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P05106(Human) O54890(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC FC

All Applications: WB:1:500-1:1,000
IHC:1:50-1:200
FC:1:50-1:100

Background: Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Purification and Purity: Peptide affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Integrin β3 polyclonal antibody detects endogenous levels of Integrin β3 protein.

Bioworld Molecular Weight: 87/110 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Integrin beta-3 on A431 (1) and rat spleen tissue (2) lysate using anti-Integrin beta-3 antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded rat ossature tissue using anti-Integrin beta-3 antibody. Counter stained with hematoxylin.

Alternative Name: GPIIIa, ITGB3, GP3A, Antigen identified by monoclonal antibody L230, CD 51, CD 61, CD51, CD51 antigen, CD61, CD61 antigen, DKFZp686A08142, GP3A, GPIIIa, Integrin alpha V, Integrin alpha V vitronectin receptor alpha polypeptide, Integrin alpha V vitronectin receptor alpha polypeptide antigen CD51, integrin alpha-V, Integrin alpha-V light chain, Integrin beta 3, Integrin beta 3 platelet glycoprotein IIIa antigen CD61, Integrin beta chain beta 3, integrinVbeta3, ITAV, ITGAV, ITGB 3, ITGB3, MSK 8, MSK8, Platelet glycoprotein IIIa, Platelet glycoprotein IIIa precursor, Platelet membrane glycoprotein IIIa, Vitronectin receptor alpha polypeptide, vitronectin receptor, Vitronectin receptor subunit alpha, VNR 1, VNR1, VNRA,

Immunogen: Peptide

Conjugate: Unconjugated

Modification: Unmodified