Product Description

Integrin alpha 1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65865-50, BS65865-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Integrins are important extracellμlar matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellμlar domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Alpha 1 integrin along with alpha 2, alpha L and alpha M has a unique inserted domain. Integrin alpha 1 is a receptor for laminin and collagen. The alpha1 subunit is also known as CD49a. CD49a associates with CD29 (beta 1 integrin), to form an alpha1 beta1 heterodimer, identified as the rat homologue to VLA1, which is involved in cellμlar adhesion to laminin and collagen.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Cow, Horse

Host: Rabbit

Applications: WB

Alternate Names: CD 49a, CD49a, CD49 antigen-like family member A, CD49a, CD49a antigen, Integrin alpha-1, ITA1_HUMAN, Itga 1, ITGA1, Laminin and collagen receptor, Very late activation protein 1, VLA 1, VLA-1, VLA1.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human Integrin alpha 1:1001-1179/1179

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: Integrin alpha 1 Polyclonal Antibody detects endogenous levels of Integrin alpha 1protein.

Molecular Weight: ~160kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -38°C long term. Avoid freeze-thaw cycles.

SwissProt: P56199

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only