Interferon alpha/beta Receptor 1 Monoclonal Antibody-MB11118

Interferon alpha/beta Receptor 1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11118-50, MB11118-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P17181

Host: Rabbit

Reactivity: Human

Applications: WB,IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Interferon alpha/beta receptor 1 in K562, HelaLysates using Interferon alpha/beta Receptor 1 antibody.

Bioworld Molecular Weight: Calculated MW: 64 kDa; Observed MW: 110-130 kDa

Specificity: IgG

Alternative Name: IFNAR1; IFNAR; Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1

Immunogen: A synthetic peptide of human Interferon alpha/beta receptor 1

Conjugate: Unconjugated

Modification: Unmodified