Involucrin Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90730-50, BS90730-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P07476(Human) P48998(Rat)
Host: Rabbit
Reactivity: Human, Rat
Applications: WB, IHC FC
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:200
Background: Involucrin is a precursor protein of the keratinocyte cornified envelope, which is formed beneath the inner surface of the cell membrane during terminal differentiation. During keratinocyte terminal differentiation, glutamine residues of involucrin become covalently cross-linked to other envelope precursors via covalent epsilon-(gamma-glutamyl) lysine bonds. Moreover, its large size allows involucrin to cross-link molecules that are separated by substantial distances in the cornified envelope. These properties allow a single involucrin molecule to form multiple cross-links, in multiple spatial planes, with other envelope precursors.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Involucrin polyclonal antibody detects endogenous levels of Involucrin protein.
Bioworld Molecular Weight: 120 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Involucrin on human skin tissue lysate using Involucrin antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Involucrin antibody. Counter stained with hematoxylin.
Alternative Name: IVL, INVO, Involucrin, IVL,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified