IOD2 Polyclonal Antibody - BT-AP10452

IOD2 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP10452-20, BT-AP10452-50, BT-AP10452-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3andapos;,5andapos;-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3andapos;-triiodothyronine, T3) by outer ring 5andapos;-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the andapos;localandapos; production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may

Research Areas: Cancer; Metabolism; Neuroscience; Signal transduction

Target Protein: DIO2

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Type II iodothyronine deiodinase

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q92813; Mouse: Q9Z1Y9; Rat: P70551

Synonyms: Type II iodothyronine deiodinase;EC 1.97.1.10;5DII;DIOII;Type 2 DI;Type-II 5'-deiodinase

GeneID: Human: 1734

Research Use Only