IOD2 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA32822-50, RA32822-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: deiodinase, iodothyronine type II (DIO2) Homo sapiens The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3, 5, 3', 5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3, 5, 3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, ELISA Clonality: Polyclonal Dilution: WB 1:500-2000 ELISA 1:5000-20000 Molecular Weight: 30 Protein Molecular Weight (kDa): 30 Storage: -20°C/1 year Human Gene ID: 1734 Human SwissProt Number: Q92813 Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Research Use Only