IOD2 rabbit pAb - ES11834

IOD2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES11834-50, ES11834-100

Citations, Manuals and MSDS Available upon request.

Background: deiodinase, iodothyronine type II (DIO2) Homo sapiens The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3, 5, 3', 5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3, 5, 3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 30kD

Human Gene ID: 1734

Human SWISS Prot NO: Q92813

Subcellular Location: Membrane; Single-pass membrane protein.

Research Use Only