Product Description

IP3KA (H431) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1959-50, BS1959-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Inositol 1, 4, 5-trisphosphate (Ins(1, 4, 5)P3) regμlates the level of calcium within the cell by releasing calcium from intracellμlar stores. Ins(1, 4, 5)P3 is phosphorylated by inositol 1, 4, 5-trisphosphate 3-kinase (IP3K) to form inositol 1, 3, 4, 5-tetrakisphosphate (Ins(1, 4, 5)P4), which is is thought to regμlate the influx of calcium across the plasma membrane. IP3K exists as three isoforms, IP3KA, B, and C. IP3KA, the most highly characterized isoform, is approximately 51 kDa and is expressed in rat brain and testis. IP3KB has a molecμlar weight of 74 kDa and is expressed in various rat tissues such as lung, thymus, testis, brain, and heart. IP3K activity is stimμlated in the presence of calmodμlin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodμlin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: 1D myo inositol trisphosphate 3 kinase A, EC 2.7.1.127, Inositol 1 4 5 trisphosphate 3 kinase A, Inositol trisphosphate 3 kinase A, IP3 3 kinase A, IP3K A, IP3KA,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 400-450 of Human IP3KA.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IP3KA (H431) polyclonal antibody detects endogenous levels of IP3KA protein.

Molecular Weight: ~ 51 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P23677

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only