Product Description

IREB2 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS47979-50, BS47979-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is an RNA-binding protein that acts to regμlate iron levels in the cells by regμlating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pμlmonary disease (COPD). Alternative splicing resμlts in mμltiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, FC

Alternate Names: ACO3, IRP2, IRP2AD, IRE-BP2, IRE-BP 2

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human IREB2

Dilution: WB: 1:1000 FC: 1:20

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 105 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P48200

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only