IRF-3 (phospho Ser396) rabbit pAb - ES5921

IRF-3 (phospho Ser396) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5921-50, ES5921-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Alternate Name: IRF3; Interferon regulatory factor 3; IRF-3

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser396. AA range:362-411

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 48-55kd

Human Gene ID: 3661

Human SWISS Prot NO: Q14653

Subcellular Location: Cytoplasm. Nucleus. Mitochondrion. Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812).

Research Use Only