IRF8 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB11123-50, MB11123-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: Q02556
Host: Rabbit
Reactivity: Human
Applications: WB,IHC-P,IP
All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Background: Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes .
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of IRF8 in THP-1Lysates using IRF8 antibody.
Bioworld Molecular Weight: Calculated MW: 48 kDa; Observed MW: 48 kDa
Specificity: IgG
Alternative Name: ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
Immunogen: Recombinant protein of human IRF8
Conjugate: Unconjugated
Modification: Unmodified