Product Description

IRF8 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7865-50, BS7865-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ICSBP (Interferon (IFN) consensus sequence-binding protein, Interferon regμlatory factor 8, IRF-8) is a transcription factor that is important for IFN-γ-mediated signaling during dendritic cell and macrophage differentiation. ICSBP physically interacts with TRAF6 (between amino acid residues 356 and 305), and this interaction of ICSBP with TRAF6 modμlates TLR signaling and may contribute to the cross-talk between IFN-γ and TLR signal pathways. ICSBP antagonizes Bcr/Abl by downregμlation of Bcl-2. ICSBP is known to interact with chromatin, and bind PU.1 in macrophages. ICSBP belongs to the IFN regμlatory factor (IRF) family that also includes IRF-1, IRF-2, and ISGF-3. These proteins are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regμlatory domain. The IRF family proteins bind to the IFN-stimμlated response element (ISRE) and regμlate expression of IFN-α and IFN-β.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IF

Alternate Names: H ICSBP, H-ICSBP, HGNC:5358, HGNC5358, HICSBP, ICSBP 1, ICSBP, ICSBP1, ICSBP1, Interferon Consensus Sequence Binding Protein 1, Interferon consensus sequence binding protein, Interferon consensus sequence-binding protein, Interferon Regμlatory Factor 8, IRF 8, IRF-8, IRF8, IRF8, IRF8_HUMAN, MYLS,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human IRF8.

Dilution: WB 1:500 - 1:2000
IF 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IRF8 polyclonal antibody detects endogenous levels of IRF8 protein.

Molecular Weight: ~ 47 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q02556

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only