Product Description

IRF8 Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Sizes: 50µl, 100µl

Catalogue Numbers: BS7865-50, BS7865-100

Swiss-Prot: Q02556

Host: Rabbit

IRF8 Polyclonal Antibody-BS7865

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human

Applications: WB, IF

All Applications: WB 1:500 - 1:2000
IF 1:50 - 1:200

Background: ICSBP (Interferon (IFN) consensus sequence-binding protein, Interferon regulatory factor 8; IRF-8) is a transcription factor that is important for IFN-γ-mediated signaling during dendritic cell and macrophage differentiation. ICSBP physically interacts with TRAF6 (between amino acid residues 356 and 305), and this interaction of ICSBP with TRAF6 modulates TLR signaling and may contribute to the cross-talk between IFN-γ and TLR signal pathways. ICSBP antagonizes Bcr/Abl by downregulation of Bcl-2. ICSBP is known to interact with chromatin, and bind PU.1 in macrophages. ICSBP belongs to the IFN regulatory factor (IRF) family that also includes IRF-1, IRF-2, and ISGF-3. These proteins are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of IFN-α and IFN-β.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IRF8 polyclonal antibody detects endogenous levels of IRF8 protein.

Bioworld Molecular Weight: ~ 47 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of THP-1 cells, using IRF8 antibody., Immunofluorescence analysis of A549 cells using IRF8 antibody.

Alternative Name: H ICSBP;
H-ICSBP;
HGNC:5358;
HGNC5358;
HICSBP;
ICSBP 1;
ICSBP;
ICSBP1;
ICSBP1;
Interferon Consensus Sequence Binding Protein 1;
Interferon consensus sequence binding protein;
Interferon consensus sequence-binding protein;
Interferon Regulatory Factor 8;
IRF 8;
IRF-8;
IRF8;
IRF8;
IRF8_HUMAN;
MYLS;

Immunogen: Recombinant full length Human IRF8.

Modification: Unmodified

Conjugate: Unconjugated