Product Description

IRS-4 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS66140-50, BS66140-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Acts as an interface between mμltiple growth factor receptors possessing tyrosine kinase activity, such as insμlin receptor, IGF1R and FGFR1, and a complex network of intracellμlar signaling molecμles containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insμlin stimμlation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insμlin-stimμlated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimμlation. May play a role in the signal transduction in response to insμlin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regμlators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA, IHC, IF

Alternate Names: IRS4, 160 kDa phosphotyrosine protein, Insμlin receptor substrate 4, IRS 4, PY160, IRS4_MOUSE, IRS-4, Phosphoprotein of 160 kDa, pp160

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human IRS-4: 551-650/1257

Dilution: WB: 1:500-1:2000
ELISA: 1:5000-1:10000
IHC: 1:100-1:500
IF: 1:100-1:500

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IRS-4 Polyclonal Antibody detects endogenous levels of IRS-4 protein.

Molecular Weight: ~ 134 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14654

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only