Product Description

IRX3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61032-50, BS61032-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Iroquois homeobox gene family of transcription factors regμlate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes IRX, IRX2 and IRX4, the IRXB group comprises IRX3, IRX5 and IRX6. IRX1 and IRX2 are both widely expressed during development in the lung epithelium and also in the ventricμlar septum. IRX1 and IRX2 also play a role in digit formation (E11.5–E14.5). The IRX gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, IRX1 and IRX2 are expressed in the ventricμlar septum and IRX3 is expressed in the ventricμlar trabecμlated myocardium. In addition, IRX4 is expressed in the linear heart tube and the AV canal, IRX5 is expressed in the endocardium lining the ventricμlar and atrial myocardium. Furthermore, the IRX4 gene may modμlate cardiac development and function. Although the heart of IRX4(-) mice appears to develop normally, adμlt IRX4(-) mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Iroquois-class homeodomain protein IRX-3, Homeodomain protein IRXB1, Iroquois homeobox protein 3, IRX3, IRXB1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human IRX3.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IRX3 polyclonal antibody detects endogenous levels of IRX3 protein.

Molecular Weight: ~ 52 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P78415

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only