ITCH Monoclonal Antibody-MB12088

ITCH Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB12088-50, MB12088-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q96J02

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteosomal degradation. Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteosomal degradation of TXNIP. Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteosomal degradation of p15 BID.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ITCH/AIP4 in A549, HL-60Lysates using ITCH antibody.

Bioworld Molecular Weight: Calculated MW: 103 kDa; Observed MW: 103 kDa

Specificity: IgG

Alternative Name: ITCH; E3 ubiquitin-protein ligase Itchy homolog; Itch; Atrophin-1-interacting protein 4; AIP4; NFE2-associated polypeptide 1; NAPP1

Immunogen: A synthetic peptide of human ITCH/AIP4

Conjugate: Unconjugated

Modification: Unmodified