ITGA2B (heavy chain, Cleaved-Leu32) rabbit pAb - ES20011

ITGA2B (heavy chain, Cleaved-Leu32) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20011-50, ES20011-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016],

Alternate Name: Integrin alpha-IIb (GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from human ITGA2B (heavy chain, Cleaved-Leu32)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 95 110kD

Human Gene ID: 3674

Human SWISS Prot NO: P08514

Subcellular Location: Membrane; Single-pass type I membrane protein.

Research Use Only