ITGAV (light chain, Cleaved-Asp891) rabbit pAb - ES20013

ITGAV (light chain, Cleaved-Asp891) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20013-50, ES20013-100

Citations, Manuals and MSDS Available upon request.

Background: integrin subunit alpha V (ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],

Alternate Name: Integrin alpha-V (Vitronectin receptor subunit alpha; CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human ITGAV (light chain, Cleaved-Asp891)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 17 110kD

Human Gene ID: 3685

Human SWISS Prot NO: P06756

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.

Research Use Only