Product Description

ITPR1 Polyclonal Antibody

Catalogue Numbers: BS61363-50, BS61363-100

Sizes: 50µl, 100µl

Alternative Name: Inositol 1,4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1;
InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor; ITPR1; INSP3R1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q14643

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ITPR1 pAb detects endogenous levels of ITPR1 protein.

Bioworld Molecular Weight: ~ 320 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of ITPR1 pAb at 1:500 dilution
Lane 1: The Brain tissue lysate of Mouse(40ug)
Lane 2: The Brain tissue lysate of Rat(40ug)
Lane 3: U-87MG whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding Human ITPR1.

Conjugate: Unconjugated

Modification: Unmodified