Product Description

Jagged1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90747-50, BS90747-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P78504(Human) Q9QXX0(Mouse) Q63722(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:1,000
IHC:1:50-1:200

Background: The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged is a membrane protein and can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Jagged is expressed in adult and fetal tissues, and expression is upregulated in cervical squamous cell carcinoma. Familial Tetralogy of Fallot, the most common form of complex congenital heart disease, is caused by a mutation in the Jagged1 gene.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Jagged1 polyclonal antibody detects endogenous levels of Jagged1 protein.

Bioworld Molecular Weight: 134 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Jagged1 antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Jagged1 antibody. Counter stained with hematoxylin.

Alternative Name: Jagged1, hJ1, JAG1, AGS, AHD, AWS, CD 339, CD339, CD339 antigen, Headturner, hJ1, Htu, Jag 1, Jag1, JAG1, Jagged 1, Jagged1 (Alagille syndrome), Jagged1, JAGL1, MGC104644, OTTHUMP00000030278, Protein jagged-1, Ser 1, Ser1, Serrate 1, Slalom,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified