Product Description

JAK1 (D1028) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5583-50, BS5583-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regμlate a spectrum of cellμlar functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimμli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regμlate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1A

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: JAK1 (D1028) polyclonal antibody detects endogenous levels of JAK1 protein.

Molecular Weight: ~ 132 kDa

Pathway: Jak Stat: IL-6 Receptor Signaling, Inhibition of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P23458

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only