Product Description

JAK2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11128-50, MB11128-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: O60674

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of JAK2 in K562, 3T3Lysates using JAK2 antibody.

Bioworld Molecular Weight: Calculated MW: 131 kDa; Observed MW: 131 kDa

Specificity: IgG

Alternative Name: JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Immunogen: A synthetic peptide of human JAK2

Conjugate: Unconjugated

Modification: Unmodified