Product Description

JAK2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS90749-50, BS90749-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regμlate a spectrum of cellμlar functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimμli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regμlate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimμlating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF

Alternate Names: JAK-2, JAK2, Janus Activating Kinase 2, Janus kinase 2 (a protein tyrosine kinase), Janus kinase 2, , JTK10, kinase Jak2, OTTHUMP00000043260, THCYT3, Tyrosine protein kinase JAK2, Tyrosine-protein kinase JAK2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein.

Dilution: WB:1:2000~1:5000
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: JAK2 polyclonal antibody detects endogenous levels of JAK2 protein.

Molecular Weight: ~ 130 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60674

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only