Product Description

JHD3B Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65184-50, BS65184-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cofactor:Binds 1 Fe(2+) ion per subunit., domain:The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails., function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate., similarity:Belongs to the JHDM3 histone demethylase family., similarity:Contains 1 JmjC domain., similarity:Contains 1 JmjN domain., similarity:Contains 2 PHD-type zinc fingers., similarity:Contains 2 Tudor domains.,

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: IHC-p, IF(paraffin, section), ELISA

Alternate Names: KDM4B, JHDM3B, JMJD2B, KIAA0876, Lysine-specific demethylase 4B, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: The antiserum was produced against synthesized peptide derived from human KDM4B. AA range:351-400

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity: JMJD2B Polyclonal Antibody detects endogenous levels of JMJD2B protein.

Molecular Weight: /

Pathway: Epigenetic Writers and Erasers of Histone H3,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O94953

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only