JNK2 Rabbit rabbit pAb - ES20702

JNK2 Rabbit rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20702-50, ES20702-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternative

Alternate Name: Mitogen-activated protein kinase 9 (MAP kinase 9; MAPK 9; EC 2.7.11.24; JNK-55; Stress-activated protein kinase 1a; SAPK1a; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2)

Source: Rabbit

Applications: WB; IHC; IF

Dilution: WB 1:500-2000, IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: Recombinant Protein of JNK2

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 46, 54kD

Human Gene ID: 5601

Human SWISS Prot NO: P45984

Subcellular Location: Cytoplasm. Nucleus. Colocalizes with POU5F1 in the nucleus.

Research Use Only