K-Ras rabbit pAb - ES8441

K-Ras rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8441-50, ES8441-100

Citations, Manuals and MSDS Available upon request.

Background: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008],

Alternate Name: GTPase KRas (K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human KRAS. AA range:150-189

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 22kD

Human Gene ID: 3845

Human SWISS Prot NO: P01116

Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Endomembrane system. Cytoplasm, cytosol.; [Isoform 2B]: Cell membrane; Lipid-anchor.

Research Use Only