KAISO Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA32902-50, RA32902-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: zinc finger and BTB domain containing 33 (ZBTB33) Homo sapiens This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear impor Reactivity: Human, Mouse Host: Rabbit Applications: WB, ELISA Clonality: Polyclonal Dilution: WB 1:500-2000 ELISA 1:5000-20000 Molecular Weight: 73 Protein Molecular Weight (kDa): 73 Storage: -20°C/1 year Human Gene ID: 10009 Human SwissProt Number: Q86T24 Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Research Use Only