Kaiso/ZBTB33 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A12900-20, A12900-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Category: Polyclonal Antibodies
Applications: WB, ELISA, ChIP
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 74kDa
Observed Molecular Weight: 74-90kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 10009
SWISS: Q86T24
Alternate Names: ZNF348; ZNF-kaiso; Kaiso/ZBTB33
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. ChIP, 5μg antibody for 10μg-15μg of Chromatin
Research Areas: Epigenetics Nuclear Signaling.
NCBI Alias: ZBTB33
Research Use Only