Product Description

KALRN Polyclonal Antibody

Catalogue Numbers: BS5704-50, BS5704-100

Sizes: 50µl, 100µl

Alternative Name: Kalirin; Huntingtin-associated protein-interacting protein; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; DUET; DUO; HAPIP; TRAD

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O60229

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB ICC

All Applications: WB: 1:500~1:1000
ICC: 1:50~1:200

Background: HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: KALRN polyclonal antibody detects endogenous levels of KALRN protein.

Bioworld Molecular Weight: ~ 192, 350 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of GPR15 pAb at 1:500 dilution
Lane 1: Hela whole cell lysate(40ug)
Lane 2: SGC7901 whole cell lysate(40ug)
Lane 3: HEK293T whole cell lysate(40ug)
Lane 4: The Uterus tissue lysate of Mouse(40ug)
Lane 5: The Uterus tissue lysate of Rat(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 895-940 of Human KALRN.

Conjugate: Unconjugated

Modification: Unmodified