Product Description

Kanadaptin(R445) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2352-50, BS2352-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: Q9BWU0

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB,

All Applications: WB: 1:500~1:1000

Background: Solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), also designated Kanadaptin or human lung cancer oncogene 3 protein (HLC-3), is a 796 amino acid protein that is widely expressed in many tissues, including kidney, lung, liver, brain and skeletal and cardiac muscle. SLC4A1AP is a multidomain protein that localizes to the nucleus where it may play a role in signaling. SLC4A1AP was previously thought to act as an adaptor protein or chaperone involved in targeting kAE1 to the plasma membrane. However, recent studies suggest SLC4A1AP does not interact with kAE1. The gene encoding SLC4A1AP maps to chromosome 2, which consists of 237 million bases and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2, including Harlequin icthyosis, sitosterolemia and Alström syndrome.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Kanadaptin polyclonal antibody detects endogenous levels of Kanadaptin protein.

Bioworld Molecular Weight: ~85 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Kanadaptin on HUVEC cells lysate. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (ER60003, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature.

Alternative Name: Kanadaptin; HLC-3; SLC4A1AP; HLC3

Immunogen: Synthetic peptide, corresponding to Human Kanadaptin.

Conjugate: Unconjugated

Modification: Unmodified