KANK2 Polyclonal Antibody
Catalogue Numbers: BS61445-50, BS61445-100
Sizes: 50µl, 100µl
Alternative Name: KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein; KANK2; ANKRD25; KIAA1518; MXRA3; SIP
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q63ZY3
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
IHC: 1:50~1:200
Background: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: KANK2 polyclonal antibody detects endogenous levels of KANK2 protein.
Bioworld Molecular Weight: ~ 117 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of KANK2 polyclonal antibody at 1:1000 dilution
Lane 1: HELA whole cell lysate (51.3μg)
Lane 2: The Uterus tissue lysate of Rat (43.4μg)
Lane 3: The Uterus tissue lysate of Mouse (37.4μg)
Lane 4: The Heart tissue lysate of Rat (43.4μg)
Lane 5: The Heart tissue lysate of Mouse (37.4μg)
Immunogen: Synthetic peptide, corresponding to amino acids 340-385 of Human KANK2.
Conjugate: Unconjugated
Modification: Unmodified