kappa Opioid Receptor Monoclonal Antibody-MB11138

kappa Opioid Receptor Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11138-50, MB11138-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P33534

Host: Rabbit

Reactivity: Rat

Applications: WB,IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Kappa Opioid Receptor in rat BrainLysates using kappa Opioid Receptor antibody.

Bioworld Molecular Weight: Calculated MW: 43 kDa; Observed MW: 60 kDa

Specificity: IgG

Alternative Name: KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1

Immunogen: A synthetic peptide of mouse Kappa Opioid Receptor

Conjugate: Unconjugated

Modification: Unmodified