KCNA5 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90762-50, BS90762-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P22460(Human) Q61762(Mouse) P19024(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC IHC FC
All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Background: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
Purification and Purity: Peptide affinity purified.
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: KCNA5 polyclonal antibody detects endogenous levels of KCNA5 protein.
Bioworld Molecular Weight: 67 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of KCNA5 on PANC-1 cell lysate using anti-KCNA5 antibody at 1/5,000 dilution., ICC staining KCNA5 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: KCNA5, ATFB7, cardiac potassium channel, HCK1, HK2, HPCN1, insulinoma and islet potassium channel, KCNA5, KCNA5, KV1.5, PCN1, potassium channel 1, Potassium channel, insulinoma and islet cell, Potassium channel, voltage-gated, shaker-related subfamily, member 5, Potassium voltage gated channel subfamily A member 5, Potassium voltage-gated channel subfamily A member 5, Voltage-gated potassium channel HK2, voltage-gated potassium channel protein Kv1.5, Voltage-gated potassium channel subunit Kv1.5,
Immunogen: Synthetic peptide within rat KCNA5 aa 230-290.
Conjugate: Unconjugated
Modification: Unmodified